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Low Dose Naltrexone

LDN is short for Low Dose Naltrexone.

Naltrexone is a drug that was approved by the FDA in 1985 to treat opiate dependence. It is marketed under the trade names, ‘Revia®’ and ‘Depade®’, and in some countries (including the United States), an extended-release formulation is available as ‘Vivitrol®’. Naltrexone is commonly used at a dose of 50mg–100mg daily for treating opiate dependence.

The term ‘LDN’ refers to the use of naltrexone at low doses; specifically between 3mg and 10mg per day. Naltrexone exhibits novel and paradox effects when administered as these low doses, as discovered byDr. Ian S. Zagon and his team at Hershey Medical Center, Penn State University in 1980.

Since this discovery, numerous laboratory and animal studies have been carried out to investigate the novel effects of LDN in cancer and autoimmune disorders. In 2007, results of the first clinical trial usingLDN were published (Smith JP et al. Am J Gastroenterol. 2007;102(4):820-8), followed by publication of a study on multiple sclerosis in 2008 (Gironi M et al. Multiple Sclerosis. 2008;14(8):1076-83) and fibromyalgia in 2009 (Younger J and Mackey S. Pain Med. 2009;10(4):663-72).

The treatments that help most, in the top right corner of the chart, are simple lifestyle changes: rest, heat, sleep, stress reduction.

While this is just one study, it suggests that the relative cost (financial and physical pain) of administering approved Fibromyalgia drugs compared to free, easy lifestyle changes should be considered when choosing a treatment for Fibromyalgia.

The rest of the results are in the graph above, which is divided into four squares…

– Top right: the most popular and effective treatments (including Rest and Heat)

– Top left: effective treatments that not many people have tried, so they may be options to think about (including LDN and Hydrotherapy)

– Lower right:  very popular but not very effective (including Lyrica and Cymbalta)

– Lower left:  neither popular nor effective (including Savella and Effexor)

Where did this data come from? This is the result of a 3-year CureTogether study on Fibromyalgia.  This is part of our regular series of research findings. Of course, with each of these findings, there is a potential bias in patient self-selection and recall. Every research study has some bias, so we present these findings as just what they are – patient-reported data – to stimulate discussion and generate new insights for further research.

What is Low Dose Naltrexone?

An example of Low Dose Naltrexone (LDN) Naltrexone is approved for alcohol and opioid dependence at 50mg doses. Pilot and preliminary studies of its use in low doses suggest there may be some positive effect for certain conditions.

Side effects

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Side effects as an overall problem

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Commonly reported side effects associated with Low Dose Naltrexone (LDN)

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Dosages

Frequently reported dosages based on patients with Fibromyalgia currently taking Low Dose Naltrexone (LDN).
 

Drugs not to take with LDN

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  • Acetyldihydrocodone
  • Actifed with Codeine Cough Syrup ®
  • Actiq ®
  • Alfenta ®
  • Alfentinil
  • Ambenyl
  • Amogel PG ®
  • Antibuse ®
  • Aspirin with Codeine
  • Astramorph PF ®
  • Avonex
  • Betaseron
  • Broncholate CS
  • Buprenex ®
  • Buprenorphine
  • Butorphanol
  • Capital and Codeine Oral Solution
  • Catapres ®
  • Cellcept
  • Cesamet ®
  • Cheracol
  • Clonidine
  • Codeine
  • Codinal PH ®
  • Darvocet ®
  • Deconsal
  • Demerol ®
  • Diabismul ®
  • Diamorphine
  • Dihydrocodeine
  • Dilaudid ®
  • Dimetane-DC Cough Syrup ®
  • Diphenoxylate
  • Disulfiram
  • Doda
  • Dolophine ®
  • Donnagel-PG ®
  • Dovolex ®
  • Dronabinol, THC
  • Duragesic ®
  • Duramorph ®
  • Emprin with Codeine ®
  • Endocet ®
  • Endocodone ®
  • Fentanyl
  • Fentora ®[/threecol_one][threecol_one]
  • Fioricet with Codeine ®
  • Fiorinal with Codeine ®
  • Heroin
  • Humira – N
  • Hycodan ®
  • Hydrocodone
  • Hydromorphone
  • Hyrocane
  • Imidium AD ®
  • Infantol Pink ®
  • Infumorph
  • Isoclor Expectorant
  • Kadian ®
  • Kaodene with Codeine®
  • Kaodene with Paregoric ®
  • LAAM
  • Laudanum
  • Levorphanol
  • Levo-Dromoran ®
  • Lomotil
  • Lorcet ®
  • Lortab ®
  • Marinol ®
  • Mellaril ®
  • Meperidine
  • Meperitab ®
  • Methadone
  • Methadose ®
  • Methotrexate
  • Morphine
  • M-Oxy
  • MSIR ®
  • Nabilone ®
  • Nalbuphine
  • Naloxone ®
  • Norco
  • Novahistine DH ®
  • Novahistine Expectorant
  • Novantrone
  • Nubain ®
  • Nucofed Expectorant
  • Numorpan ®
  • Numorphone ®
  • OMS
  • Opana ®
  • Opium
  • Oramorph
  • Oxycodone
  • Oxycontin
  • OxyIR[/threecol_one]

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  • Oxymorphone
  • Paracodine ®
  • Paregoric
  • Par-Glycerol-C (CV)
  • Pentazocine
  • Percocet ®
  • Percodan ®
  • Pethidine
  • Pediacof ®
  • Phenaphen with Codeine ®
  • Phenergan with Codeine ®
  • Phenergan VC ®
  • Poly-Histine
  • Promethazine VC with Codeine
  • Propoxyphene
  • Rebif
  • Remicade – Must be off 50 days
  • Remifentinil
  • Rescudose
  • Robitussin A-C ®
  • Robitussin DAC ®
  • Roxanol
  • Roxicodone ®
  • Soma with Codeine
  • Stadol ®
  • Sublimaze ®
  • Suboxone
  • Subutrex ®
  • Sufenta ®
  • Sufentinil
  • Talwin ®
  • Thioridazine
  • Triaminic Expectorant with Codeine ®
  • Tussionex
  • Tussi-Organiden
  • Tylox
  • Tysabri
  • Tussar-2 ®
  • Tussar SF ®
  • Ultiva ®
  • Vicodin ®
  • Vicoprofen
  • Xodol
  • Zydone[/threecol_one_last][divider] 
    Historical information, and potential uses of LDN, visit:
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